Chronic heartburn linked to one of the fastest-growing cancers in America
Cancer/by Stuart Spechler, MD, AGAF, FACG/Apr 22, 2019
We all experience the occasional bout of heartburn, or acid
reflux, especially after a particularly large or fatty meal. Although uncomfortable,
that burning sensation in your chest likely doesn’t cause much concern.
But did you know that heartburn has actually been linked to
esophageal cancer?
Chronic heartburn, often caused by gastroesophageal reflux
disease, or GERD, puts
you at risk of developing a type of esophageal cancer called adenocarcinoma — one
of the fastest-growing cancers in America.
GERD causes acid made by the stomach to splash backward into
the esophagus, resulting in a variety of uncomfortable symptoms, including
frequent heartburn, nausea, bad breath, regurgitation and respiratory problems.
Over time, GERD causes your esophagus to become inflamed,
increasing your risk for a condition called Barrett’s
esophagus, a known risk factor for esophageal cancer that affects the
tissue of your esophagus. Barrett’s esophagus typically does not cause any
symptoms beyond those associated with GERD and can therefore often goes
undiagnosed.
So, when should you worry about heartburn being a sign of something more serious? Here’s when acid reflux might warrant a visit to your doctor:
If your heartburn does not respond quickly to over-the-counter medications.
If you also are experiencing difficulty swallowing.
If you are losing weight for no apparent reason.
If you are having frequent fevers.
If you are passing black stools.
Innovating
better screening and treatment options
At the Center
for Esophageal Diseases at Baylor University Medical Center, my colleagues
and I have been conducting research to further our understanding of Barrett’s
esophagus and its relationship to esophageal cancer, and to help innovate better
treatment techniques. With esophageal cancer on the rise, it’s critical that we
discover better ways to address Barrett’s esophagus, the primary risk factor
for this type of cancer.
For example, our recent studies have shown that GERD causes
the cells that line Barrett’s esophagus to burrow into deeper layers of the
esophagus, where they can escape detection and be shielded from endoscopic treatment. We
are now actively studying how to prevent this burrowing process, so that we can
identify worrisome changes early on in Barrett’s esophagus.
Understanding how this condition develops and acts over time
can help improve
our ability to eradicate Barrett’s esophagus once and for all — and decrease
people’s risk of esophageal cancer.
While this type of esophageal
cancer is rare, the
context for developing this cancer should still be on your radar. This is particularly the case if
you experience regular heartburn and you are 50 years of age or older.
When Barrett’s esophagus is identified early and treated properly, cancer can
be prevented.
Stuart Spechler, MD, AGAF, FACG, is a gastroenterologist on the medical staff at Baylor Scott & White Center for Esophageal Diseases. Dr. Spechler specializes in diseases of the esophagus, including gastroesophageal reflux disease, Barrett's esophagus, eosinophilic esophagitis and esophageal motility disorders such as achalasia. He attended medical school at Boston University School of Medicine in Massachusetts. His internship, residency and GI fellowship took place at Boston VA Medical Center.
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